Plugin releases

[oahadzhanian.datagrok.ai]

Bio 2.27.5 - 2.27.11 (2026-05-15) docs, release notes

Features:

• HELMCore monomer library: Added distinct colors for RNA sugars, linkers, and conjugates based on their chemistry, for easier visual identification

Bug Fixes:

• Sequence Space / Sequence Activity Cliffs: Show a clear error message when no table or Macromolecule column is open, instead of failing silently

[vmakarichev]

EDA 1.5.5 (2026-05-26) docs

This release adds Welch’s ANOVA - a robust alternative to classical one-way ANOVA when group variances are unequal.

[oserhiienko]

Chem 1.17.9 (2026-05-26): docs, release notes

Bug Fixes:

• Scaffold tree:
  • Removed the lingering colors fragments column when the last color-coded node is deleted one-by-one (previously only cleaned up on viewer detach or “Drop all trees”)
  • Fixed severe load/scroll slowdown on large dataframes — molecule rendering and substructure searches now run only for on-screen nodes instead of the entire tree
  • Deduplicated per-node bitset computation (reuses in-flight and completed searches) and added a one-time shared fingerprint warm-up, eliminating redundant full-column searches on load
  • Debounced scroll-driven substructure searches so fast scrolling no longer spawns a search for every node scrolled past
• Chem Space: Guard editor entry against null current dataFrame / missing Molecule column to prevent NullError
• Chem: Toxicity Risks: Avoid ‘Column already exists’ crash on repeat invocation
• GROK-20108: Docker API: Throw a clear error when the chem-chem container is not available

[oserhiienko]

Chem 1.17.10 (2026-05-28): docs, release notes

Features:

• Chem: Record all generated reaction results in the enumerator

[vmakarichev]

EDA 1.5.6 (2026-06-04) docs

Features:

• Added two-sample t-test:
  • Welch
  • Student
• Added control comparison tests:
  • Dunnett’s
  • Holm-corrected Welch’s t-tests
• Improved reporting in ANOVA

[oahadzhanian.datagrok.ai]

Bio 2.27.15 (2026-06-10) docs, release notes

Features:

• Linear Translation: Added support for complex entities, including multiple linkers, conjugates, and multi-phosphates

[oahadzhanian.datagrok.ai]

Sequence Translator 1.10.24 - 1.10.26 (2026-06-10) docs, release notes

Features:

• OligoNucleotide renderer:
  • Improved duplex strand alignment using HELM strand annotations and pairing information.
  • Added automatic duplex alignment for sequences without explicit strand pairing information.
  • Improved rendering of backbone linkers (such as p and [sp]) throughout oligonucleotide structures.
• Oligo context panel: Added duplex alignment information, including overhang detection and alignment source.
• Oligo Structures panel: Improved strand ordering to better reflect sense/antisense roles.

[oahadzhanian.datagrok.ai]

HELM 3.0.0 - 3.0.1 (2026-06-20) docs, release notes

Features:

• Migrated to the Datagrok HELM Web Editor
• Added a new HELM Service, editor, parsing and rendering
• Added HELM editor panes for molecular structure, composition and conversion
• Monomer highlighting in HELM grid cells: Highlighted monomers are now marked with a translucent overlay in response to macromolecule highlight events
• Improved RNA splitting with support for complex RNA and complex triplets, and more inclusive matching

Bug Fixes:

• Fixed async renderer invalidation

[oahadzhanian.datagrok.ai]

Bio 2.28.0 - 2.28.2 (2026-06-22) docs, release notes

Features:

• Migrated to the standalone HELM Web Editor
• To Atomic Level: Molecule size is now configurable via column tags, with a clearer message when the monomer limit is exceeded

Bug Fixes:

• Fixed HELM substructure filter editor sizing
• Monomer library now fully resets on reload

[oahadzhanian.datagrok.ai]

Sequence Translator 1.11.0 - 1.11.3 (2026-06-23) docs, release notes

Features:

• Migrated to the standalone HELM Web Editor
• Markush enumeration:
  • Added an R-group template picker with a built-in catalogue of common substituents (alkyl, aryl, heteroaryl, halogens, amines, protecting groups); copy R-groups between positions, append or replace with de-duplication, and export to CSV.
  • Added automatic duplicate removal by canonical SMILES and support for custom result table names.
  • Added admin-configurable Markush defaults to seed cores, R-groups, enumeration modes, and output options, distributed per user group.

[vmakarichev]

EDA 1.6.2 (2026-06-24) docs

Migrated ML kernels to Rust/WebAssembly:

• PCA
• Multivariate analysis
• Linear regression
• Softmax

[oahadzhanian.datagrok.ai]

Dendrogram 1.4.15 (2026-06-23) docs, release notes

Features:

• Cluster assignment improvements: Added optional per-cluster medoid metrics, including Medoid Rank (where 1 indicates the most representative item, enabling Top-N extraction) and Avg Distance to Cluster (the mean distance from each member to all other members in the cluster). These metrics are computed per cluster without materializing the full distance matrix.